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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
08.01.05  Expand sub section  Other antineoplastic drugs
Cytotoxic Drug Aflibercept (Zaltrap®)
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Link  NICE TA307: Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
   
Alectinib (Alecensa®)
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Atezolizumab (Tecentriq®)
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Link  NICE TA492: Atezolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
   
Axitinib (Inlyta®)
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Link  NICE TA333: Axitinib for advanced renal cell carcinoma
   
Bosutinib (Bosulif®)
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Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
   
Ceritinib (Zykadia)
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Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
   
Durvalumab (Imfinzi ®)
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Link  NICE TA578; Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation
   
Cytotoxic Drug Eribulin (Halaven®)
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Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
Link  NICE TA515: Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen
   
Ibrutinib (Imbruvica®)
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Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Link  NICE TA491: Ibrutinib for treating Waldenstrom’s macroglobulinaemia
Link  NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
   
Idelalisib (Zydelig®)
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Link  NICE TA359: Chronic lymphocytic leukaemia - Idelalisib
Link  NICE TA604:Idelalisib for treating refractory follicular lymphoma (TA604)
   
Ixazomib (Ninlaro®)
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Link  NICE TA505: Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
   
Pablociclib (Ibrance®)
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Cytotoxic Drug Panitumumab (Vectibix®)
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Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
   
Cytotoxic Drug Panobinostat (Farydak®)
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Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
   
Ponatinib (Iclusig®)
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Link  NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
   
Ramucirumab (Cyramza®)
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Link  NICE TA403: Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancer
   
Ruxolitinib (Jakavi®)
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Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
   
Trifluridine-tipiracil (Lonsurf®)
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Venetoclax (Venclyxto®)
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Link  NICE TA487: Venetoclax for treating chronic lymphocytic leukaemia
Link  NICE TA561; Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia (TA561)
   
Daratumumab (Darzalex®)
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Red
High Cost Medicine

FOC until comissioned by NHSE.

 
Link  NICE TA510: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
Link  NICE TA573; Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma (TA573)
   
LarotrectinibBlack Triangle (Vitrakvi®)
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as per andrew email from mmc may 2020

 
   
Rucaparib (Rubraca®)
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Link  NICE TA611:Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer (TA611)
   
LorlatinibBlack Triangle (Lorviqua®)
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NHS England

NHSE routinely comissioned-CDF then NHSE- from 90 day following publication of the final treatment guidelines.

 
Link  NICE TA628: Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancer (TA628)
   
08.01.05  Expand sub section  Amsacrine
08.01.05  Expand sub section  Arsenic trioxide
08.01.05  Expand sub section  Bevacizumab
Bevacizumab (Avastin®)
(Oncology)
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Link  NICE TA214: Breast Cancer with taxane
Link  NICE TA263: Breast cancer with capecitabine
Link  NICE TA285: Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab
   
08.01.05  Expand sub section  Bexarotene to top
08.01.05  Expand sub section  Bortezomib
Cytotoxic Drug Bortezomib (Velcade®)
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Link  NICE TA129: Multiple myeloma - bortezomib
Link  NICE TA228: 1st line treatment of multiple myeloma
Link  NICE TA311: Bortezomib for induction therapy in multiple myeloma
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
   
08.01.05  Expand sub section  Brentuximab vedotin
Brentuximab vedotin (Adcetris®)
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Link  NICE TA446 : Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA478L Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
Link  NICE TA577; Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma (TA577)
   
08.01.05  Expand sub section  Cetuximab
Cetuximab (Erbitux®)
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Link  NICE TA145: Head and neck cancer - cetuximab
Link  NICE TA176: Colorectal cancer (first line) - cetuximab
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
Link  NICE TA473: Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
   
08.01.05  Expand sub section  Crisantaspase
08.01.05  Expand sub section  Dacarbazine and Temozolomide to top
Cytotoxic Drug Dacarbazine
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08.01.05  Expand sub section  Erlotinib
08.01.05  Expand sub section  Hydroxycarbamide
Cytotoxic Drug Hydroxycarbamide
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08.01.05  Expand sub section  Imatinab
08.01.05  Expand sub section  Ipilimumab
08.01.05  Expand sub section  Mitotane to top
08.01.05  Expand sub section  Panitumumab
08.01.05  Expand sub section  Pentostatin
08.01.05  Expand sub section  Platinum compounds
Cytotoxic Drug Carboplatin
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Cytotoxic Drug Cisplatin
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Cytotoxic Drug Oxaliplatin
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Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
   
08.01.05  Expand sub section  Porfimer sodium and temoporfin
08.01.05  Expand sub section  Procarbazine to top
Cytotoxic Drug Procarbazine
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08.01.05  Expand sub section  Protein kinase inhibitors
Abemaciclib (verzenios ®)
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Link  NICE TA563; Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer (TA563)
   
Afatinib (Giotrif®)
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Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
   
Crizotinib (Xalkori®)
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Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
   
Dasatinib (Sprycel®)
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Link  NICE TA241: CML where treatment with imatinib has failed
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Erlotinib (Tarceva®)
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Everolimus (Afinitor®)
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Link  NICE TA348: Preventing Rejection in Liver Transplant
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Gefitinib (Iressa ®)
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Link  NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Cytotoxic Drug Imatinib (Gilvec®)
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Lapatinib (Tyverb®)
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Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
   
Nilotinib (Tasigna®)
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Link  NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
Link  NICE TA251: Dasatinib, nilotinib and imatinib for first line treatment of CML
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Cytotoxic Drug Temsirolimus (Torisel®)
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08.01.05  Expand sub section  Taxanes
Cytotoxic Drug Cabazitaxel (Jevtana®)
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Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
   
Cytotoxic Drug Docetaxel (Taxotere®)
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Link  NICE TA101: Prostate cancer (hormone-refractory) - docetaxel
Link  NICE TA109: Breast cancer (early) - docetaxel
   
Cytotoxic Drug Paclitaxel
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Link  NICE TA108: Breast cancer (early) - paclitaxel
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
   
Paclitaxel (Abraxane®)
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08.01.05  Expand sub section  Topoisomerase I inhibitors
Cytotoxic Drug Irinotecan Hydrochloride
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Cytotoxic Drug Topotecan (Hycamtin®)
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Link  NICE TA183: Cervical cancer (recurrent) - topotecan
Link  NICE TA184: Lung cancer (small-cell) - topotecan
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Expand sub section  Trabectedin
08.01.05  Expand sub section  Trastuzumab to top
Cytotoxic Drug Pertuzumab (Perjeta®)
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Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Link  NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
Link  NICE TA569; Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer (TA569)
   
Cytotoxic Drug Trastuzumab (Herceptin®)
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Link  NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
Link  NICE TA34: Breast cancer - trastuzumab
   
Cytotoxic Drug Trastuzumab emtansine (Kadcyla®)
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Link  NICE TA458 : Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxan
   
08.01.05  Expand sub section  Tretinoin
Tretinoin (Vesanoid®)
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08.01.05  Expand sub section  Vismodegib
 ....
Key
note Notes
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Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
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Link to adult BNF
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Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
Homecare
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